IBD-RESPONSE is a UK-wide multi-centre observational cohort study that will develop a predictive algorithm for response or failure to respond to biologic, janus kinase inhibitor (JAKi) and sphingosine-1-phosphate receptor (S1PR) modulator therapies in Crohn's disease and ulcerative colitis.

Launched in 2022 our precision medicine research will follow 1,325 patients for the first year after commencing one of these therapies.

We will utilise multiple cutting edge technologies to study the gut microbiome, the human genome and immune system integrated with clinical outcome data utilising machine learning techniques.

Click on the image to watch our video and find out more

Meet the Team!

Meet the team of clinicians and scientists that are working hard to set up IBD-RESPONSE at 40 centres across the UK

impact clinical practice?

IBD-RESPONSE may shape how clinicians and patients tailor individual treatment choices for IBD in the future

What is CD-metaRESPONSE?

Read more about CD-metaRESPONSE and how it differs to and complements IBD-RESPONSE

Are you a clinical team interested in taking part in IBD-RESPONSE?

Find out more information about the study from our Chief Investigator, and how your involvement will make a difference to the future of IBD treatment

If you'd like to get in touch with us to find out more information, please follow the 'contact us' tab in the menu above.

Published Work

Check below to see a summary of our published work within IBD-RESPONSE 

Defining predictors of responsiveness to advanced therapies in Crohn’s disease and ulcerative colitis: protocol for the IBD-RESPONSE and nested CD-metaRESPONSE prospective, multicentre, observational cohort study in precision medicine

Click on the link below to read the protocol for both IBD-RESPONSE and CD-metaRESPONSE

Protocol paper

Considerations for peripheral blood transport and storage during large-scale multicentre metabolome research

Read about our latest letter, published in Gut, which investigates the impact of different storage times and temperatures on the plasma metabolome.

Summary Research letter